Sufentanil conversion and pharmacology
Extremely potent synthetic opioid primarily used in operating rooms and intensive care settings (500-1000x morphine).
Equianalgesic estimate
5-10x more potent than Fentanyl (10-20mcg Parenteral ≈ 10mg Parenteral Morphine)
Published equianalgesic ratios vary between references and with clinical context. Read how to interpret conversion results before applying an estimate.
Mechanism of action
Extremely potent mu-opioid receptor agonist. Highly lipophilic.
Brand names: Sufenta, Dsuvia (sublingual)
Pharmacokinetics
- Protein binding
- ~93%
- Volume of distribution
- 1.7-2.5 L/kg
- Half-life
- 2.5-3 hours (elimination half-life after IV). Context-sensitive half-time varies with infusion duration.
| Route | Form | Bioavailability | Onset | Peak | Duration |
|---|---|---|---|---|---|
| Parenteral | IV | — | 1-3 min | 3-5 min | Dose-dependent (very short after single bolus due to rapid redistribution) |
| Sublingual | SL | ~53% | 30 min | 60 min | 2-4 hours |
Metabolism
- CYP3A4 (N-dealkylation)
- O-demethylation
Metabolites
- Norsufentanil Inactive.
Rapidly metabolized by the liver. High extraction ratio. Major CYP3A4 substrate.
Renal and hepatic impairment
Renal
Pharmacokinetics relatively unchanged; generally considered safe.
Hepatic
Clearance may be reduced; use caution.
Clinical cautions
- Extreme potency requires meticulous dosing.
- High risk of respiratory depression and chest wall rigidity.
- Restricted to closely monitored anesthetic or specialized acute care settings.
For qualified healthcare professionals. This page is an educational reference, not prescribing advice. Check medicine information and conversion factors against a current clinical source and local guidance.
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Last updated 30 August 2026. Read how to interpret conversion results and the Terms of Service.