Supported Opioid Medications

Comprehensive database of opioid medications with accurate equianalgesic conversion factors and morphine milligram equivalent (MME) calculations for safe prescribing.

Clinical Warning

All opioid conversions should be used as a guide only. Always consider individual patient factors, cross-tolerance, and start with lower doses when rotating opioids. Consult current clinical guidelines and institutional protocols.

Morphine

Strong Opioid

Gold standard opioid for pain management and MME calculations

Routes:Oral, IV, IM, SC

Half-life:2-4 hours

Common Doses:

15mg

30mg

60mg

Reference standard for equianalgesic conversions

Oxycodone

Strong Opioid

Commonly prescribed oral opioid for moderate to severe pain

Routes:Oral

Half-life:3-5 hours

Common Doses:

5mg

10mg

15mg

20mg

30mg

1.5x more potent than oral morphine

Oxymorphone

Strong Opioid

Potent semi-synthetic opioid for severe pain management

Routes:Oral, IV, IM, SC

Half-life:7-9 hours

Common Doses:

5mg

10mg

15mg

20mg

3x more potent than oral morphine

Hydromorphone

Strong Opioid

Potent opioid used for severe pain management

Routes:Oral, IV, IM, SC

Half-life:2-3 hours

Common Doses:

2mg

4mg

8mg

7.5x more potent than oral morphine

Fentanyl

Strong Opioid

Highly potent synthetic opioid for severe chronic pain

Routes:Transdermal, IV, Sublingual

Half-life:3-7 hours (IV), 17 hours (patch)

Common Doses:

12mcg/hr

25mcg/hr

50mcg/hr

75mcg/hr

100mcg/hr

100x more potent than morphine

Sufentanil

Strong Opioid

Ultra-potent synthetic opioid for anesthesia and severe pain

Routes:IV, Epidural, Sublingual

Half-life:2-3 hours

Common Doses:

0.1mcg/kg

0.2mcg/kg

0.5mcg/kg

1000x more potent than morphine, primarily used in anesthesia

Methadone

Strong Opioid

Long-acting opioid with complex conversion ratios

Routes:Oral

Half-life:8-59 hours

Common Doses:

5mg

10mg

20mg

Complex conversion due to variable potency ratios

Codeine

Weak Opioid

Mild to moderate pain relief, prodrug of morphine

Routes:Oral

Half-life:2.5-4 hours

Common Doses:

15mg

30mg

60mg

0.15x potency of morphine, genetic variation affects metabolism

Tramadol

Weak Opioid

Unique dual-mechanism analgesic for moderate pain

Routes:Oral, IV

Half-life:6-7 hours

Common Doses:

50mg

100mg

150mg

200mg

0.1x potency of morphine, serotonin/norepinephrine activity

Tapentadol

Strong Opioid

Dual-mechanism opioid with reduced side effects

Routes:Oral

Half-life:4 hours

Common Doses:

50mg

75mg

100mg

0.3x potency of morphine, norepinephrine reuptake inhibition

Hydrocodone

Strong Opioid

Commonly prescribed combination opioid in the US

Routes:Oral

Half-life:3.8 hours

Common Doses:

5mg

7.5mg

10mg

Equal potency to morphine, often combined with acetaminophen

Buprenorphine

Partial Agonist

Partial μ-opioid receptor agonist with ceiling effect

Routes:Sublingual, Transdermal, IV

Half-life:24-42 hours

Common Doses:

2mg

8mg

5mcg/hr

10mcg/hr

Partial agonist with unique conversion considerations

Equianalgesic Conversion Guidelines

• All conversions are approximate and should be used as starting points

• Consider incomplete cross-tolerance when rotating opioids (typically reduce by 25-50%)

• Individual patient factors affect opioid response and metabolism

• Monitor patients closely when initiating or changing opioid therapy

• Follow CDC guidelines for opioid prescribing and MME calculations