Dihydrocodeine conversion reference
Check OpioidCalc's OME factors by route, then open the formulation-specific pharmacology, cautions and supporting sources.
Educational reference for qualified healthcare professionals. Conversion factors estimate oral morphine equivalent daily dose. They are not a recommended switching dose. Confirm the result with a current source and local guidance.
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Current OpioidCalc factors
Multiply the dose or delivery rate in the stated units by the factor to estimate mg oral morphine equivalent per day. These are the factors currently used by OpioidCalc. Methadone uses 4.7 when converting methadone to OME.
| Route | Input units | OME factor |
|---|---|---|
| Oral | mg/day | 0.1 |
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Formulations and cautions
Choose a formulation to read its pharmacology, population, limitations and source references.
OralDefault in appModified-release tablet
App source review: 27 August 2026
View details and sources
Modified-release tablet
App source review: 27 August 2026
View details and sources- Formulation behaviour
- Prolonged release supports twice-daily administration at 12-hour intervals.
Population: Adults described in the cited product information
Applicability: France
- Limitation: The authorised interval is not proof of a precise clinical effect duration.
- DICODIN L.P. 60 mg prolonged-release tablet RCP4.2, 5.1 and 5.2. France. Source revised 10 March 2025. App review 27 August 2026. Regulatory product information.
- Receptor activity
- Pure opioid agonist; some effects are attributed to the active metabolite dihydromorphine.
Population: Adults described in the cited product information
Applicability: France
- Limitation: Product-specific evidence; do not transfer to other formulations.
- DICODIN L.P. 60 mg prolonged-release tablet RCP5.1 Pharmacodynamic properties. France. Source revised 10 March 2025. App review 27 August 2026. Regulatory product information.
- Metabolism
- Demethylation, oxidation and conjugation occur; CYP2D6 forms dihydromorphine.
Population: Adults described in the cited product information
Applicability: France
- Limitation: Product-specific evidence; do not transfer to other formulations.
- DICODIN L.P. 60 mg prolonged-release tablet RCP5.2 Pharmacokinetic properties. France. Source revised 10 March 2025. App review 27 August 2026. Regulatory product information.
- Active metabolites
- Dihydromorphine is pharmacologically active.
Population: Adults described in the cited product information
Applicability: France
- Limitation: Product-specific evidence; do not transfer to other formulations.
- DICODIN L.P. 60 mg prolonged-release tablet RCP5.2 Pharmacokinetic properties. France. Source revised 10 March 2025. App review 27 August 2026. Regulatory product information.
- Elimination
- Metabolites are eliminated mainly in urine.
Population: Adults described in the cited product information
Applicability: France
- Limitation: Product-specific evidence; do not transfer to other formulations.
- DICODIN L.P. 60 mg prolonged-release tablet RCP5.2 Pharmacokinetic properties. France. Source revised 10 March 2025. App review 27 August 2026. Regulatory product information.
- Renal impairment
- A reduced starting dose and individual adaptation are advised in renal impairment.
Population: Adults described in the cited product information
Applicability: France
- Limitation: Product-specific evidence; do not transfer to other formulations.
- DICODIN L.P. 60 mg prolonged-release tablet RCP4.2 Posology. France. Source revised 10 March 2025. App review 27 August 2026. Regulatory product information.
- Hepatic impairment
- A reduced starting dose and individual adaptation are advised in hepatic impairment.
Population: Adults described in the cited product information
Applicability: France
- Limitation: Product-specific evidence; do not transfer to other formulations.
- DICODIN L.P. 60 mg prolonged-release tablet RCP4.2 Posology. France. Source revised 10 March 2025. App review 27 August 2026. Regulatory product information.
Sources used on this page
Other medicine references
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